LPSL filter cartridges are specially designed for sterilizing filtration of plasma fractionation. They are featuring extremely low extractables with no more than 10mg/10”, longer service life with 40 cycles of SIP. These filters can powerfully ensure final product quality.

Features and Benefits
● Double layer hydrophilic PES Membrane
● Low protein binding
● Extensive drug compatibility for critical applications
● Extremely low extractables

Quality
● Cartridges produced in a controlled environment
● Manufactured according to ISO9001 certified Quality Management System

Ordering Information
LPSL Low Extractable and Longer Service Life Filter Cartridge for Plasma Fractionation
Application:
● Plasma Fractionation
● Sterile Injection Powder
● Vaccines
● Sterile Injection Powder
● Small & Large Volume Parenterals
● Plasma Fractionation
● Ophthalmic Solutions
● Facilities Water
● Cell Culture Media Preparation
● Active Pharmaceutical Ingredients
● Beer Filtration
● Wine Filtration
● Bottled Water Filtration
● Soft Drink Filtration
● Dairy Filtration
● High Fructose Syrup Filtration
● Semicon Filtration
● Ultrapure/DI Water Filtration
● Photoresist Filtration
● Display Filtration
● CMP Slurry Filtration
● Inkjet Inks Filtration
● Water Filtration
● Chemicals Filtration

LPSL Low Extractable and Longer Service Life Filter Cartridge for Plasma Fractionation

Materials of Construction
Membrane	Double Layer Hydrophilic PES
Support	PP
Core, Cage and Drainage	PP
End Caps	PP (222/226 with encapsulated stainless   steel reinforcing ring)
O-rings/Gasket	Silicone/EPDM/Viton
Sealing technology	Thermal Bonding, No Adhesives
Dimensions
Diameter	Φ70
Length	5 inch, 10 inch, 20 inch, 30 inch
Filtration   Area, ft2
≥ 4.9 per 10-inch cartridge
Pore Size, μm
0.45+0.22
Maximum Differential Pressure
Forward: 4.2 bar @ 23 ℃; 1.5   bar @ 85 ℃
Integrity Test at 23 ℃
Water bubble point	≥ 3500 mbar (50 psig)
Diffusive flow	≤ 30ml/min/10”@2.8bar
Bacterial Retention
Passed the bacterial   challenge testing using Brevundimonas diminuta (ATCC19146) at a minimum challenge concentration of 1 x 107 CFU/cm2.
Extractables, per 10-inch cartridge
≤ 10 mg after 24-h soak in   water
Effluent Particle Level
Meets the requirements   of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Non-Fiber Releasing
Meets the criteria for   a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Toxicity
Component materials   meet GB/T 14233.2of Chinese National Standard for Safety Tests.
TOC
< 500 ppb after a water flush of 60 liters per 10-inch cartridge
Multiple Sterilization Cycles
40 steam-in-place sterilization or autoclave cycles of 30 min at 123℃
Oxidizable Substances
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
Bacterial Endotoxins
< 0.25 EU/ml as determined by the LAL test